Monday, August 29, 2011

Hippocratic Method

Share |

Hippocrates (460-370)
Medical schools give early instruction to students in the proper manner in which to interview and examine their first patients. Textbooks stress listening skills, objectivity, and using one’s mind and senses as precision instruments of analysis. These words might very well have come from Hippocrates two thousand four hundred and fifty years ago.

Hippocrates was the first to treat medicine as a science. Early Hellenic physicians were essentially surgeons or sophists dealing with external injuries, leaving the rest to the Gods. Hippocrates dissociated medicine from mythology and rituals. He brought together the loose medical knowledge in medical schools where he taught, systematizing that knowledge into his teachings and text.  He, furthermore, gave physicians their highest moral inspiration.

The Hippocratic method came to entail the studied bedside manner and inductive reasoning that characterize the best internists and clinicians today. The art consisted of clinical inspection, observation, a flexible and critical mind-set, and a continuous search for a source of error. Hippocrates insisted upon a careful systematic thorough examination of the patient with consideration of facial appearance, pulse, temperature, respirations, palpation, urine, sputum, feces, pain and movement. He insisted on transparency, honesty and non-judgmental impersonal objectivity. This bedside method, distinctive of all true clinicians from Sydenham to Osler, formed the basis of scientific medicine.

Professionally, Hippocrates stressed the dignity of the physician and respect of the patient including confidentiality and trust. That simple axiom, 2450 years ago, brought honor and privilege to the medical profession for centuries to come. As such, Hippocrates remains the father of Internal medicine.  His accuracy in description of disease with few changes and few additions would serve in current medical texts. Physicians continued the use of his texts -- especially on malaria and tuberculosis -- up through the 18th century.  The Hippocratic method fell out of common use after Hippocrates’s death but revived in the 17th century.

Hippocrates’s aphorism on diabetes, based on tasting the patient’s urine for sugar and his treatment with a diet of red meat and sour wine struck me as amazing. Hippocrates practice and teachings were at the height of Athenian democracy. He was contemporary to Sophocles, Plato, and Socrates. Never before or since has there been so much genius in so little time and space.
   

Tuesday, August 23, 2011

Armed Forces Institute of Pathology

Share | Who was the genius who decided to close the AFIP as an "obscure little agency" with no current military relevance?  http://www.nature.com/news/2011/110817/full/476270a.html Nature476, 270-272 (2011)

Announced in 2005 as part of an armed forces budget cut, AFIP will close its doors 15 September. The AFIP budget was only 93 million, yet its value to clinical medicine world wide was and is beyond calculation. AFIP would be nearing its 150th anniversary, founded by General Wm. Hammond in 1862.

AFIP with pathology specimens including: 55 million slides, 31 million paraffin blocks and 500,000 wet specimens and some 800 expert employees with the most advanced equipment for the analysis and identification of submitted tissue; acted as a backup and final arbitrator of difficult medical diagnosis. AFIP received more than 50,000 requests for second opinion each year, making changes or additions to over half of these. The diagnostic capabilities were greater than even the teaching hospitals, and the AFIP was recognised world wide in this regard.

For example as given by Alison Mccook's article in Nature, two high-grade lymphomas can be difficult to distinguish using the usual staining techniques. AFIP, however can distinguish these two using molecular and immunohistochemical techniques that most hospitals lack. The two lymphomas have very different treatments. Treating the wrong diagnosis could result in the patients death. There are many such cases with critical need for a correct diagnosis.

Given that 15% of diagnoses are wrong in the first place and as many as 50% are found inadequate or wrong at autopsy, the loss of AFIP, which provided a low cost backup for us all, amounts to an international tragedy. 

Once again, persons given the high level and studied responsibility for making decisions effecting clinical medicine, who do not know anything about medicine create more problems than they solve.

In the course of my clinical years, I sent specimens to AFIP maybe only two times, but each was critical to the patient, and the answer made a difference. What I remember them mostly for, however, was the tray of some 200 microscope slides depicting various pathologies sent on loan for study at little or no cost -- as a student, priceless.